Clinicopathological MRI and CSF correlates of iron accumulation, neurodegeneration and neuroinflammation in Huntington*s disease.

Clinicopathological MRI and CSF correlates of iron accumulation, neurodegeneration and neuroinflammation in Huntington*s disease. - MRI and CSF pathological correlates in HD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54707

Enrollment

Registered

2019-08-12

Start date

2021-08-11

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Huntington's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male and female individuals with an age of 18 years and older; Ability to undergo MRI scanning; For individuals diagnosed with HD, a positive genetic test with a CAG repeat expansion of > 36 in the HTT gene is required; For pre-manifest participants a positive genetic test with a CAG repeat expansion of >= 40 in the HTT gene is required.

Exclusion criteria

Exclusion criteria: Contra-indications to MRI scanning and lumbar puncture; Pregnancy; Severe chorea; Inability to understand the information about the protocol; Severe physical restrictions.

Design outcomes

Primary

Measure	Time frame
The main study parameter are the striatal and cortical QSM measures, in combination with CSF markers for iron, neurodegeneration and neuroinflammation, in een Huntington populatie, in vergelijking tot gezonde controle deelnemers.	—

Secondary

Measure	Time frame
- Outcome measurement of clinical (neurologisch and psychological) and genetic tests and their correlation with iron accumulation. - Neuroinflammation metabolites, levels and characteristics, as measured with (DW-)MRS iin combinaties with QSM measures en neuroinflammation - biomarkers in CSF, in a Huntington's Disease population, as compared with healthy controls.	—

Countries

Netherlands

Outcome results