Psychosis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: For patients: 1. Diagnosis of a psychotic disorder or bipolar disorder For all participants: 1. In case of participants from the GROUP or Bipolar Genetics study; provided past consent to be re-contacted for future studies. 2. Give written informed consent for the current study 3. Age 18 years or older 4. First degree family members of the included patients can participate, irrespective of having a psychiatric diagnosis or not. 5. Controls subjects must not have an affective or non-affective diagnosis, nor in their first-degree family members.
Exclusion criteria
Exclusion criteria: - No demonstration of adequate understanding of the purpose, procedures, risks, benefits, emergency contacts, and payment issues. - Unable to give consent to all aspects of the study. - Ferrous objects in or around the body (e.g. braces, tattoos, piercings, metal fragments; small braces are allowed - Pacemaker or other stimulatory devices/leads that are not temporarily removable from the body without health hazards - Claustrophobia - History of closed head injury - History of neurological illness or endocrine dysfunction - Neurological abnormalities as well as structural brain abnormalities that may interfere with the measurements, identified through neurodiagnostic evaluation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimates of brain activation during task performance. | — |
Secondary
| Measure | Time frame |
|---|---|
| Performance on the 3 PVS tasks, answers to questions (collected via self-report and interviews) on current demographics, clinical situation, motivational behaviour, and personality. | — |
Countries
Netherlands
Outcome results
None listed