Multisystem phenotyping of severe ACUte asthma at the Paediatric Intensive Care Unit

Multisystem phenotyping of severe ACUte asthma at the Paediatric Intensive Care Unit - MACU-PICU

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54638

Enrollment

Registered

2019-10-21

Start date

2022-09-05

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: - Between 2-18 years of age - Referred to a PICU with severe acute asthma for which intravenous salbutamol is started (according to the criteria of the Dutch protocol for status asthmaticus, clinical judgement of the attending physician and asthma scores). -Written informed consent obtained from the parents/ local guardians/ patient when 12 years of older. -Patients included in the SysPharmPediA study (NL 55788.041.15) with unstable asthma GINA step 3.

Exclusion criteria

Exclusion criteria: - Cystic Fibrosis - Previous inclusion in the study

Design outcomes

Primary

Measure	Time frame
Severe acute asthma phenotypes at the PICU based on differences in bacterial metabolomics and microbiomics, viromics, breathomics, transcriptomics and cytokine biomarkers.	—

Secondary

Measure	Time frame
None applicable.	—

Countries

Netherlands

Outcome results