esophageal cancer
Conditions
Interventions
Paravertebral catheter analgesia in patients who undergo minimally invasive
esophagectomy.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The study population consists of patients who are scheduled to undergo elective minimally invasive esophagectomy with two-field lymphadenectomy, gastric conduit reconstruction, and intrathoracic anastomosis (i.e. Ivor Lewis procedure).
Exclusion criteria
Exclusion criteria: - ASA >III / severe comorbidity - Coagulation disorders that prohibit epidural analgesia according to the Nederlandse Vereniging voor Anesthesiologie (NVA) guideline *Neuraxisblokkade en antistolling* - Other contraindications for epidural analgesia - Allergy to local anesthetics - Ongoing opioid use (i.e. any opioid) prior to esophagectomy (i.e. >3 months calculated until the day of esophagectomy) - Renal failure, i.e. eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the quality of recovery on postoperative day 3, measured by the *Quality of Recovery - 40 (QoR-40)* questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures include the need for escape pain medication, additional opioid consumption, technical complications, length of intensive care and hospital stay, postoperative complications, quality of life at 3 and 6 months after surgery, pain at 6 months after surgery, and cost-effectiveness. | — |
Countries
Netherlands
Outcome results
None listed