granulosa cell tumour Ovarian cancer
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
No minimum to 99 Years
Inclusion criteria
Inclusion criteria: Women (of any age) o Diagnosed with a granulosa cell tumour (now or in the past) OR; o Suspected of a GCT, scheduled for surgery
Exclusion criteria
Exclusion criteria: If histopathological examination after surgery shows a diagnosis other than a granulosa cell tumour, this patient will be excluded and will not be followed during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of the proposed investigation is the identification of novel therapeutic targets in granulosa cell tumours, by first identifying common mutations or other genetic alterations and subsequently performing drug screens in tumour organoid cell cultures to study the effect of targeting the observed aberrations in human granulosa cell tumour samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| The presence of circulating tumour DNA (ctDNA) in plasma of granulosa cell tumour patients, and its value as a diagnostic marker for tumour load. | — |
Countries
Netherlands
Outcome results
None listed