Fitness-to-Drive and Risk acceptance in Huntington's disease

Fitness-to-Drive and Risk acceptance in Huntington's disease - FTDr in HD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54606

Enrollment

Registered

2015-11-13

Start date

2016-01-18

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Huntington's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Confirmed diagnosis of Huntington*s Disease via CAG-repeat length analysis Between 18 and 74 years of age. Dutch speaking. Hold a drivers* licence.

Exclusion criteria

Exclusion criteria: Individuals who do not meet the inclusion criteria

Design outcomes

Primary

Measure	Time frame
Development of cognitive profiles to assess FTDr in HD patients determined by an regression analysis. For each variable z-scores will be calculated. These z-scores will then be combined into four categories: 1. Cognitive speed and attention including the following test variables: Rey complex figure, TMT-A, Stroop I-III, SDMT, Category fluency, ATAVT, and RT S1-S2. 2. Executive functions, including the following test variables: TMT-B, Letter fluency, and SWOV. 3. Social cognitive functions, including the following test variables: FEEST and IGT. 4. Procedural driving skills, including the following test variables: Swingdrives fixed and free, Intersections, and Merging. With these categories we will perform a regression analysis to determine the predictive value of each category for FTDr in HD.	—

Measure

Time frame

Development of cognitive profiles to assess FTDr in HD patients determined by an regression analysis. For each variable z-scores will be calculated. These z-scores will then be combined into four categories: 1. Cognitive speed and attention including the following test variables: Rey complex figure, TMT-A, Stroop I-III, SDMT, Category fluency, ATAVT, and RT S1-S2. 2. Executive functions, including the following test variables: TMT-B, Letter fluency, and SWOV. 3. Social cognitive functions, including the following test variables: FEEST and IGT. 4. Procedural driving skills, including the following test variables: Swingdrives fixed and free, Intersections, and Merging. With these categories we will perform a regression analysis to determine the predictive value of each category for FTDr in HD.

—

Secondary

Measure	Time frame
Other questions that will be addressed during the course of the study are: • Is there a relationship between levels of self-awareness, as measured by tests that call upon self-awareness (i.e. the SWOV, WRBTV, and Swingdrive), and the result of the on-road driving test? • What is the relationship between UHDRS motor score and FTDr?	—

Countries

Netherlands

Outcome results