The sequestration pattern of thrombocytes in healthy adults: results of the ITP liver and spleen scan.

The sequestration pattern of thrombocytes in healthy adults: results of the ITP liver and spleen scan. - Sequestration Pattern Of Thrombocytes in healthy adults (SPOT)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54593

Enrollment

Registered

2019-07-03

Start date

2021-04-28

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune Trombocytopenia (ITP)

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy, as determined by screening assessments and judgement of researchers >18 years old Informed consent

Exclusion criteria

Exclusion criteria: Pregnancy or planning to become pregnant during the study period Liver disease (Child Pugh >7) Hematological/ platelet/ bone marrow disease in history or in co-existence Autoimmune disease in history or in co-existence Transplantation in history (Partial) splenectomy in history Any other clinically relevant history as determined by screening assessments and the judgement of the researchers , •(Suspected) allergy to one of the isotopes or contents used for platelet scintigraphy

Design outcomes

Primary

Measure	Time frame
The platelet sequestration pattern (% splenic, % hepatic, %mixed) in healthy subjects.	—

Secondary

Measure	Time frame
Platelet counts before and after scan (x10^9/ L) Platelet half life (in hours) Mean platelet life span (in hours) Mean platelet turnover (in hours) Labelling percentage (in %) Percentage of platelets remaining in the circulation after 48 hours (in %) Differences between sequestration patterns in healthy adults an ITP patients (in S:L ratio) Differences between sequestration patterns in heathy individuals over time (in S:L ratio)	—

Measure

Time frame

Platelet counts before and after scan (x10^9/ L) Platelet half life (in hours) Mean platelet life span (in hours) Mean platelet turnover (in hours) Labelling percentage (in %) Percentage of platelets remaining in the circulation after 48 hours (in %) Differences between sequestration patterns in healthy adults an ITP patients (in S:L ratio) Differences between sequestration patterns in heathy individuals over time (in S:L ratio)

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Countries

Netherlands

Outcome results