UMBRELLA PROTOCOL SIOP-RTSG 2016 Integrated research and guidelines for standardized diagnostics and therapy for paediatric renal tumours

UMBRELLA PROTOCOL SIOP-RTSG 2016 Integrated research and guidelines for standardized diagnostics and therapy for paediatric renal tumours - UMBRELLA PROTOCOL SIOP-RTSG 2016

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54547

Enrollment

1050

Registered

2019-02-25

Start date

2019-06-07

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nefroblastoma Wilms tumour

Interventions

None listed

Eligibility

Age

No minimum to 64 Years

Inclusion criteria

Inclusion criteria: All children, adolescents or young adults with a primary or relapsed renal tumour diagnosed in a participating SIOP-RTSG centre are eligible for inclusion in the SIOP 2016 UMBRELLA study.

Exclusion criteria

Exclusion criteria: The only exclusion criterion is missing informed consent.

Design outcomes

Primary

Measure	Time frame
Study parameters: - 1q gain and other copy number variants - Radiological parameters (including diffusion-weighted imaging, DWI) for histological subtype - Blastemal volume Outcome: - Overall survival - Event-free survival - Relapse-free survival	—

Secondary

Measure	Time frame
Study parameters: - Mutations in individual known Wilms tumour genes (including WT1, CTNNB1, AMER1, TP53, MYCN, FBXW7, GPC3, MLLT1, DIS3L2, DICER1, DROSHA, DGCR8, SIX1 and SIX2) - miRNA as biomarker in blood, urine and tumour samples Outcomes: - Overall survival - Event-free survival - Relapse-free survival	—

Countries

Netherlands

Outcome results