Parkinson Parkinson's disease
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Prior to enrollment in this clinical investigation, candidates must meet ALL of the following criteria: Patients: • recently diagnosed with PD (N=625; time since Parkinson diagnosis 2 & 65 years) in both patient groups, will be attempted. • 18 years or older; • able to read and speak Dutch • Providing IRB-approved Informed Consent; • Willing, competent and able to comply with all aspects of the protocol, including follow-up schedule and biospecimen collections. Controls: • 18 years or older • Healthy (Self-report) • Is able to read and speak Dutch • Even distribution with respect to gender and age of the patient groups will be attempted • Providing IRB-approved Informed Consent; • Willing, competent and able to comply with all aspects of the protocol, including follow-up schedule and biospecimen collections.
Exclusion criteria
Exclusion criteria: Patients • Patients who received brain surgery for Parkinson*s disease, patients who currently use levodopa continuous intestinal gel or patients who are currently receiving apomorphine treatment. • presence of co-morbidities that would hamper interpretation of parkinsonian disability, in the opinion of the lnvestigator. • MoCa score of
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| main study parameters are biomarker concentrations (i.e. blood, CSF & feces), skin alpha-synuclein (a-syn) aggregation, ADR occurrence and cognition scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| nvt | — |
Countries
Netherlands
Outcome results
None listed