asthma and well-being of children in puberty, adolescents and young adults asthma and well-being of children in puberty, youngsters and young adults
Conditions
Interventions
None
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
12 Years to 64 Years
Inclusion criteria
Inclusion criteria: Adolescents and young adults who reached the age of 12-24 years and who already participated in the WHISTLER-0 and/or WHISTLER/Cardio and/or WHISTLER/Cardio2 study, and who's parents and subject are willing to give informed consent to participate in this study. From age 16, informed consent will be obtained from the adolescent only. Adolescents and young adults aged 12-24 years who already participated in the WHISTLER round aged 12-16 years consisting of only online questionnaires, because of the corona epidemic, will be included. This group, which consists of around 300 children, will be approached for this new WHISTLER/ Adolescent & Young Adult round since it consists of new physical measurements and an amended online questionnaire.
Exclusion criteria
Exclusion criteria: There are no exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 1: cIMT and PWV as cardiovascular outcomes. Part 2: lung function measurements (spirometry). Part 3: QoL, happiness, well-being and resilience will be measured using validated questionnaires. Part 4: different markers of disease activity defined through questionnaires, physical examination and markers in the blood, depending on the chronic disorder, will be examined in the WHISTLER population. | — |
Secondary
| Measure | Time frame |
|---|---|
| Part 1: Carotid artery distension using ultrasound. Endothelial functioning using flow mediated dilation. Dyslipidemia using a lipid panel including total cholesterol, total triglycerides, apolipoprotein B (ApoB), lipoprotein a (Lp(a)), HDL- and LDL-cholesterol and HbA1c. Inflammation using CRP levels. Intra-abdominal and subcutaneous fat measured by ultrasound. Part 2: Allergic sensitization patterns and specific IgE-profiling in the blood next to reported allergies by a questionnaire. Part 3: Biological stress marker hair cortisol. | — |
Countries
Netherlands
Contacts
Public ContactD.E. Bruil
Universitair Medisch Centrum Utrecht
Outcome results
None listed