Heart failure
Conditions
Interventions
ketone ester drink vs. placebo
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: HFrEF - Chronic Heart Failure NYHA II - III - LVEF= 5 - LVEF >= 45 % - Stable for the last 1 month prior to the study
Exclusion criteria
Exclusion criteria: HFrEF - Age 80% of expected and or/a cycling time of 40 kg/m2; - Unable to understand study procedures; - Unable or unwilling to provide informed consent. HFpEF - Age 80% of expected and or/a cycling time of 40 kg/m2 - Estimated glomular filtration rate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate and magnitude of change in PCr and Pi concentrations from baseline to maximum exercise. These parameters inform on the integrated homeostatic performance of oxidative and glycolytic ATP synthetic networks in muscle during exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Post-exercise recovery rate of PCr and Pi concentrations. These rates inform on mitochondrial ATP synthetic function - Rates and magnitude of change in intramuscular pH during exercise and recovery. These parameters inform on the magnitude of anaerobic, glycolytic ATP synthesis. - Maximal exercise performance. | — |
Countries
Netherlands
Outcome results
None listed