Imaging Radiotherapy-induced brain injury using advanced MRI and PET, a pilot

Imaging Radiotherapy-induced brain injury using advanced MRI and PET, a pilot - Imaging Radiotherapy-induced brain injury using MRI and PET

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54488

Enrollment

Registered

2021-09-16

Start date

2022-01-27

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain injury after radiotherapy

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - adults (>18 years), - referred for treatment of tumours located in nasopharynx, parotids, oropharynx, skull base and sinonasal cavity (under which meningioma, pituitary, chondrosarcoma, chondroma) with radiotherapy (photons or protons), with or without systemic treatment, with a close proximity of 2 cm of the clinical target volume (CTV elective dose) to the brain or brainstem.

Exclusion criteria

Exclusion criteria: - age

Design outcomes

Primary

Measure	Time frame
Main study parameters/endpoints: The occurrence, location and appearance of brain microvascular and white matter radiotherapy-induced changes on sequentially obtained MRI & PET images performed in several time points in comparison with the baseline MRI and PET images and conventional MRI images.	—

Countries

Netherlands

Outcome results