Psoriasis Psoriasis Vulgaris
Conditions
Interventions
Patients undergo regular 595 nm pulsed dye laser therapy for psoriasis. Tissue
samples will be collected from the patients using a total of two 3 mm
punch-biopsies under local anesthesia. These samp
Sponsors
ZBC Multicare B.V.
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18 - 69 years of age - Psoriasis vulgaris - Skin type I - III - At least two lesions with of surface area of 3 cm2 - Contralateral psoriasis vulgaris lesions located on at least one of the following locations: * trunk * upper arms * upper legs
Exclusion criteria
Exclusion criteria: The participant receives other treatments for psoriasis or affecting during the study or two weeks before the start of the study The participant suffers from any known neurological, vascular, or immunological condition other than psoriasis. The participant is allergic to lidocain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the difference in ratio between linear nerve density to linear blood vessel density between the pre-treatment, and post-treatment biopsies. This will be named the recovery ratio (nerves/blood vessels). The tested hypothesis is that laser therapy results in a decrease in nerve fibre density. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to assess any relationship between the dermal architecture (in terms of blood vessels and nerves) and leukocyte infiltration before and after SPT treatment. | — |
Countries
Netherlands
Outcome results
None listed