corona smell and taste disorders
Conditions
Interventions
None listed
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: patients (18-60 years) with persistent (> 1month) self-reported smell loss within three months after COVID-diagnosis. For the neuroimaging substudy: patients (18-60 years) with persistent (> 1month) self-reported smell loss after COVID-diagnosis.
Exclusion criteria
Exclusion criteria: any pre-existing olfactory or gustatory disorders ( i.e. more than 2 weeks prior to the covid-infection) for the neuroimaging subpart: pregnant, or intending to become pregnant during the course of the study Having a contra-indication to MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective assessment of parosmia by means of the SSParoT; Objective olfactory function by means of Sniffin*Sticks; Objective gustatory function by means of Taste Strips. With this, we will assess longterm prevalence of parosmia within the cohort, as well as describe the smell and taste ability of patients. Mean and median time interval to clinical improvement (recovery) will be reported as measure of duration of parosmia. For the neuroimaging part: differences in olfactory bulb volume, differences in volume of olfactory-related brain regions, and differences in activation of brain regions upon odor stimuli between patients with smell loss (i.e. anosmia and hyposmia) and parosmia will be analyzed. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the longterm prevalence of anosmia, hyposmia, and taste loss. To measure smell and taste function subjectively longitudinally in a cohort of Covid-19 patients with self-reported smell loss. To assess the impact of smell/taste changes on eating behavior and quality of life. To assess changes over time in olfactory bulb volume, volume of olfactory-related brain regions over time, and functional responses in a subset of Covid-19 patients | — |
Countries
Netherlands
Outcome results
None listed