Rickettsial infection exotic and/or emerging arboviral and other infection rare and exotic diseases from which some are transmitted by mosquito and other insects
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: *adult and fully capable person *written informed consent provided *strong clinical suspicion by infectious disease clinical specialists of infection with rare/emerging or exotic viruses or Rickettsiae spp based on signs and symptoms in combination with relevant travel history and/or activities presenting at any departments or out-patient clinic of the EMC or confirmed positive external patients/participants (Figure 1, Appendix 1 and 2). Patients will be approached and included by infectious disease clinical specialists, by their treating physician or through municipal public health services or recruited via advertisement.
Exclusion criteria
Exclusion criteria: *written Informed consent NOT provided *
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary end point: creation of a sample pool for diagnostic test development and validation of rare/emerging or exotic viruses and Rickettsia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end points: 1, to gain knowledge about the kinetics of viral infections and Rickettsiae spp infection; 2. to test the suitability of body fluids and eschar swab for diagnostic use; 3. concordance between PCR test results, virus isolation and (neutralizing) antibody (IgM, IgG) responses; 4. presence and persistence of other markers (e.g. IgM, IgG, IgA, IgE). | — |
Countries
Netherlands
Outcome results
None listed