COMPRehensive assessment of prevalence, risk factors and mechanisms of impaired medical and psychosocial health outcomes among Adolescents and Young Adults with cancer: the prospective observational COMPRAYA cohort study

COMPRehensive assessment of prevalence, risk factors and mechanisms of impaired medical and psychosocial health outcomes among Adolescents and Young Adults with cancer: the prospective observational COMPRAYA cohort study - COMPRAYA cohort study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54428

Enrollment

4000

Registered

2020-05-05

Start date

2021-06-18

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tumor

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - COMPRAYA 1.0 All AYAs diagnosed with cancer for the first time between 18-39  years of age, 3 months ago after diagnosis up to max 6 months after diagnosis  in 1 of the participating centers Mentally competent; sufficient understanding of the Dutch language.  COMPRAYA 2.0 All AYAs diagnosed with cancer for the first time between 18-39  years of age from 1999 or later (COMPRAYA 2.0), who are at least two years post-diagnosis at the time of study invitation, treated in one of the participating centers Mentally competent; sufficient understanding of the Dutch language.

Exclusion criteria

Exclusion criteria: - Mentally incompetent patients based on the opinion of treating physician. - Inability to understand the Dutch language -Place of residency at time of cancer diagnosis outside the Netherlands -Diagnosed and/or treated in a hospital outside the Netherlands - Life expectancy less than 6 months based on the opinion of treating physician.  - Those already participating in COMPRAYA 1.0 will not be included in COMPRAYA 2.0.

Design outcomes

Primary

Measure	Time frame
The main outcomes are medical (e.g. second tumour; survival; fertility) and psychosocial (e.g. distress) health outcomes. Other study parameters (covariates/moderators/mediators) are characteristics of the individual (e.g. age, sex, cultural background, partner status, educational level, occupation, tumour type, disease stage, body composition, comorbid conditions, coping style), characteristics of the environment (e.g. cancer treatment, lifestyle), and genetic and biological factors (e.g. family history of cancer, stress and inflammation markers (e.g. cortisol, IL-6), microbiome). Primary Objective: - To identify individual, environmental, biological and psychological characteristics of AYA cancer patients who are at high risk for impaired medical and psychosocial health outcomes. In other words: To develop a prediction model for impaired medical and psychosocial health outcomes (at baseline, 2-, 5- and 10-year follow-up).	—

Measure

Time frame

The main outcomes are medical (e.g. second tumour; survival; fertility) and psychosocial (e.g. distress) health outcomes. Other study parameters (covariates/moderators/mediators) are characteristics of the individual (e.g. age, sex, cultural background, partner status, educational level, occupation, tumour type, disease stage, body composition, comorbid conditions, coping style), characteristics of the environment (e.g. cancer treatment, lifestyle), and genetic and biological factors (e.g. family history of cancer, stress and inflammation markers (e.g. cortisol, IL-6), microbiome). Primary Objective: - To identify individual, environmental, biological and psychological characteristics of AYA cancer patients who are at high risk for impaired medical and psychosocial health outcomes. In other words: To develop a prediction model for impaired medical and psychosocial health outcomes (at baseline, 2-, 5- and 10-year follow-up).

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Secondary

Measure	Time frame
Secondary Objective(s): -To assess the prevalence of impaired (age-specific) medical (e.g. second tumour) and psychosocial (e.g. social isolation) health outcomes at each time point (at baseline, 2-, 5- and 10-year follow-up). Exploratory Objective(s): -To analyse the course of medical and psychosocial health outcomes over time (all timepoints needed) -To analyse mediating mechanisms associated with impaired health outcomes in AYA cancer patients (at baseline, 2-, 5- and 10-year follow-up). Other Objective(s): -To form a prospective observational cohort of patients diagnosed with cancer at AYA age, and follow them over time until death.	—

Measure

Time frame

Secondary Objective(s): -To assess the prevalence of impaired (age-specific) medical (e.g. second tumour) and psychosocial (e.g. social isolation) health outcomes at each time point (at baseline, 2-, 5- and 10-year follow-up). Exploratory Objective(s): -To analyse the course of medical and psychosocial health outcomes over time (all timepoints needed) -To analyse mediating mechanisms associated with impaired health outcomes in AYA cancer patients (at baseline, 2-, 5- and 10-year follow-up). Other Objective(s): -To form a prospective observational cohort of patients diagnosed with cancer at AYA age, and follow them over time until death.

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Countries

Netherlands

Contacts

Public ContactWTA van der Graaf

Antoni van Leeuwenhoek (AVL)

w.vd.graaf@nki.nl0205126993

Outcome results