baarmoederomstandigheden en IVF behandeling Uterus characteristics
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Reproductive age (18-43 years old) Regular menstrual cycle Normal transvaginal ultrasound Planned ICSI treatment due to (severe) male factor subfertility or planned fertility treatment with donor sperm Written informed consent
Exclusion criteria
Exclusion criteria: Unexplained subfertility, tubal infertility or premature ovarian failure The presence of untreated unilateral or bilateral hydrosalpinx A history of dilatation and curettage Previous caesarean section with niche formation Malformation of the urogenital system Endometriosis Untreated/unsubstituted endocrine abnormalities (e.g. pituitary, thyroid, adrenal or pancreas abnormalities). PCOS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study outcomes will be the mean (SD) temperature and the mean (SD) pH measured in the uterine cavity of women from a Dutch population at the time of the menstrual cycle an embryo normally implants, and the average concentration (mean ± SEM) of at least thirty-seven components present in fluid aspirated from the uteri of the same women at the same time. | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference between the primary results and previous results from the uteri of Iranian women and the difference between the primary results and the current human embryo culture conditions for human IVF, determined with an independent T-test (temperature and pH) or one-way ANOVA (uterine fluid components). | — |
Countries
Netherlands
Outcome results
None listed