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*EffeCt of lung ultrasOuNd-guided Fluid deresuscItation on Duration of vEntilation iN intensive Care unit patiEnts (CONFIDENCE-trial)*

*EffeCt of lung ultrasOuNd-guided Fluid deresuscItation on Duration of vEntilation iN intensive Care unit patiEnts (CONFIDENCE-trial)* - CONFIDENCE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON54414
Enrollment
1000
Registered
2021-11-29
Start date
2021-12-22
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

respiratory failure mechanical ventilation respiratory failure

Interventions

LUS-guided fluid deresuscitation
decisions on start and speed of fluid deresuscitation are guided by LUS findings.

Sponsors

Amsterdam UMC
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - admitted to one of the participating ICUs; and - expected to be under invasive ventilation for longer than 24 hours

Exclusion criteria

Exclusion criteria: (a) age

Design outcomes

Primary

MeasureTime frame
Number of ventilator-free days and alive at day 28 (*VFD-28*)—

Secondary

MeasureTime frame
ICU- and hospital length of stay; ICU-, hospital- and 90-day mortality; cumulative fluid balance at successive days; proportion of patients who develop kidney injury or atrial fibrillation.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Apr 17, 2026