cerebral small vessel disease vascular cognitive impairment
Conditions
Interventions
Use of 7 Tesla MRI for detailed brain scans. The ultra-high field 7T MRI system is widely used in scientific research, and since its initial introduction in the 1990s, no serious side effects have bee
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient group: Admitted to the memory or the geriatric clinic of the LUMC, the memory clinic of the Alrijne hospital in Leiden, or the memory clinic of the Haga hospital in the HagueFrom 65 years of ageOlder adult age- and sex-matched control group: Not be admitted to a memory clinic, nor be diagnosed with mild cognitive impairment or any form of dementiaFrom 65 years of ageYounger adult control group: Between 18 and 35 years of ageNot be admitted to a memory clinic nor be diagnosed with mild cognitive impairment or any form of dementiaEligible for MRINative-level Dutch speaker
Exclusion criteria
Exclusion criteria: Only for the older adult control group: A score of 26 or lower on the Mini-Mental State Examination (MMSE)ClaustrophobiaContraindications for MRI such as metal implants and pacemakerUse of benzodiazepinesInitiated treatment with antidepressants less than 6 weeks prior to inclusion Not being able to provide written informed consent (assessed by the treating physician)Individuals that have been declared mentally incapacitated*Other severe neurological disease (besides dementia-related for the patient group)Cognitive impairment due to known other neurological diseasePrevious brain surgery *A declaration of mental incapacity has wide going consequences for the subject. Discussion about participation in this study should not be used as a basis for such a decision. The treating physician assesses at the study visit if the patient is able to sign informed consent and is able to participate in the study based on his/her own free will.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the association of a more complex WMH shape with abnormalities in small vessel morphology within the patient group. | — |
Secondary
| Measure | Time frame |
|---|---|
| First of all, to study the association between WMH shape and cognition/other cerebral small vessel disease markers within the patient group. Secondly, to study the association of novel MRI markers of glymphatics with cerebral SVD markers and cognition within the patient group. Next, to study glymphatics marker changes with age between the younger and older adult control groups. Lastly, to study glymphatics marker changes related to dementia and SVD between the patient group and age- and sex-matched older adult control group. | — |
Countries
Netherlands
Contacts
Public ContactI Eiling
Leids Universitair Medisch Centrum
Outcome results
None listed