(1) cholestatic liver diseases (2) fibrosing cholangiopathies
Conditions
Interventions
The only additional procedure that subjects will undergo is bile aspiration
during ERCP.
The ERCP endoscope will be equipped with a 5-French catheter that is inserted
through an existing channel i
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * * 18 years of age * Already planned to undergo one of the following elective procedures: endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography with drainage of the bile ducts, liver biopsy, segmental liver resection, Whipple procedure, pylorus preserving pancreaticoduodenectomy * Diagnosed with either: primary sclerosing cholangitis, primary biliary cholangitis, lgG4-Related Disease, pancreatitis, liver metastasis of primary coloncarcinoma, choledocholithiasis, liveradenoma, suspected pancreatic tumour, cholangiocarcinoma * able to provide informed consent
Exclusion criteria
Exclusion criteria: Pregnancy Clinically unstable patients (as assessed by treating physician) Patients admitted to the ICU
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the structure, composition and function of the biliary HCO3- umbrella in cholangioids and liver biopsies derived from fibrosing cholangiopathy subjects compared to non-fibrosing cholangiopathy subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Compare the effects of potentially therapeutic agents such as UDCA conjugates, norUDCA, FXR agonists and fibrates on the biliary HCO3- umbrella in order to protect cholangioids against the malicious effects of toxic bile acids. | — |
Countries
Netherlands
Outcome results
None listed