Energieverbruik energy use Metabolic rate
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Provision of signed and dated informed consent prior to any study specific procedures • Willingness to comply with study protocol • Apparently healthy men and women as judged by the study physician • Non-smoking • Aged between 18 and 35 years • BMI >=20 and
Exclusion criteria
Exclusion criteria: • Having a medical condition or use of medication which might lead to an intensified response towards LPS exposure to be judged by the study physician • Having a medical condition or history which might impact study measurements to be judged by the study physician (e.g. myocardial infarction, angina, thrombosis, stroke, cancer, liver or bowel disease or diabetes) • Use of over-the-counter and prescribed medication, which may interfere with study measurements (to be judged by the principal investigator and physician) • Use of oral antibiotics (with the exception of topical antibiotics) in 40 days or less prior to the start of the study • Current use of antihypertensive, antidiabetic or lipid lowering medication • Females who are pregnant, breast feeding or may wish to become pregnant during the study • Abnormal ECG result • Fasting glucose >7.0 mmol/L • Total cholesterol >8.0 mmol/L • Clinically significant out of range values of serum levels of liver, kidney and pancreatic enzymes, to be judged by the study physician • Anaemia, Hb-level 25 kg/m2 • Reported alcohol consumption > 14 units/week (female) or > 21 units/week (male) • History of illicit drug use • Reported weight loss or gain of 3 kg or more during a period of 2 months prior to screening • Active blood donor (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is energy metabolism in apparently healthy volunteers. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters are substrate oxidation, glucose and lipid metabolism, hepatic, kidney and pancreatic function, vascular function, oxidative stress and clinical and inflammatory parameters. | — |
Countries
Netherlands
Outcome results
None listed