Lymphomics; improving the understanding of the anatomy of the lymphatic system and the direction and velocity of lymph flow

Lymphomics; improving the understanding of the anatomy of the lymphatic system and the direction and velocity of lymph flow - Lymphomics; improving the understanding of lymph

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54295

Enrollment

Registered

2022-01-05

Start date

2023-04-07

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymph flow disorder

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - 18 years and older (no restriction for sex) - willing and able to have dynamic MR scanning in the Radboudumc - written informed consent

Exclusion criteria

Exclusion criteria: - unsuitable for MRI (metallic object in the body, severe claustrophobia) - pregnancy - kidney problems - liver cirrhosis - cardiovascular disease - medication use

Design outcomes

Primary

Measure	Time frame
Main study parameter/endpoint: Anatomical measurements of both the thoracic duct and the cisterna chyli (conducted in the coronal plane on whichever MR sequence offers the best visualization of these structures). Measurements consist of the maximal diameter of the thoracic duct and the diameter at the level of the diaphragm, and the width and length of the cisterna chyli. Lymph flow velocity will determined by distance covered over time in cm/min. This will be calculated for both retroperitoneal lymph vessels and the thoracic duct. Thoracic duct outlet location and patency will be determined using contrast-enhanced ultrasound imaging of the left and right neck. Other study parameters: Patient characteristics such as: age, gender, body weight. Due to the effect of dietary intake on flow (specifically dietary fat intake), time since last meal, number of calories and fat content will be recorded and analyzed.	—

Measure

Time frame

Main study parameter/endpoint: Anatomical measurements of both the thoracic duct and the cisterna chyli (conducted in the coronal plane on whichever MR sequence offers the best visualization of these structures). Measurements consist of the maximal diameter of the thoracic duct and the diameter at the level of the diaphragm, and the width and length of the cisterna chyli. Lymph flow velocity will determined by distance covered over time in cm/min. This will be calculated for both retroperitoneal lymph vessels and the thoracic duct. Thoracic duct outlet location and patency will be determined using contrast-enhanced ultrasound imaging of the left and right neck. Other study parameters: Patient characteristics such as: age, gender, body weight. Due to the effect of dietary intake on flow (specifically dietary fat intake), time since last meal, number of calories and fat content will be recorded and analyzed.

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Secondary

Measure	Time frame
Secondary study parameters/endpoints: Not applicable.	—

Countries

Netherlands

Outcome results