Influence of Positive End-Expiratory Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children

Influence of Positive End-Expiratory Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children - IPCOM

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON54287

Enrollment

Registered

2023-05-11

Start date

2023-03-01

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory insufficiency

Interventions

Adjustment of Positive End-Expiratory Pressure (PEEP) at different levels.

Eligibility

Age

No minimum to 11 Years

Inclusion criteria

Inclusion criteria: All patients aged 0 - 5 years who are mechanically ventilated for at least 24 hours

Exclusion criteria

Exclusion criteria: - Physical restrains (e.g. syndromal disorders) making it impossible to obtain required images - Aortic stenosis - Congenital heart defects resulting in a single ventricle physiology. - Patients on ECMO - Patients who are haemodynamically unstable - premature birth with gestational age corrected for post-conceptional age less than 40 weeks - congenital or acquired neuromuscular disorders - congenital or acquired central nervous system disorders with depressed respiratory drive - severe traumatic brain injury (i.e. Glasgow Coma Scale

Design outcomes

Primary

Measure	Time frame
Cardiac output at different levels of PEEP	—

Secondary

Measure	Time frame
Secondary objectives included a) assessment of right ventricular parameters at different levels of PEEP, b) relationship of changes in primary outcome to respiratory mechanics and c) influence of phase of illness on these parameters.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)