atrial fibrillation cardiac arrhythmia
Conditions
Interventions
Patients will be randomized to receive MgSO4 (bolus of 10 mmol and continuous
infusion of 3 mmol/hour MgSO4 depending on serum Mg2+ level or Ringer*s lactate
initiated directly post induction of ane
Sponsors
HagaZiekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Elective cardiac surgery (valve surgery and/or CABG) - 18 years and above
Exclusion criteria
Exclusion criteria: - History of atrial fibrillation (AF) or atrial flutter - Concomitant rhythm associated procedures (MAZE (surgical ablation)/PVI (pulmonary vein isolation)) - Pre-existing severe renal impairment (eGFR0.1 mcg/kg/min) - Development of third-degree heart block during index admission or pre-existing 3rd degree heart block without pacemaker presence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the incidence patients with POAF in the first 7 days post-surgery has been defined as primary endpoint. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include duration of POAF, peak heart rate during POAF, Length of Hospital stay (LOHS) and ICU Length Of Stay (LOS), duration of mechanical ventilation, inotropic and/or vasopressor support, combined outcome of 28-day mortality, stroke, pulmonary embolism, delirium (requiring anti-psychotic medication), infection requiring antibiotics and POAF. | — |
Countries
Netherlands
Outcome results
None listed