There is no specific disease being investigated There is no specific disease being investigated
Conditions
Interventions
None listed
Sponsors
Spinoza Centre for Neuroimaging
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Healthy english-speaking volunteers between 21 and 55 years old; Male or female; At least one previous experience with a hallucinogenic substance, but not in the 4 weeks prior to the beginning of the study.
Exclusion criteria
Exclusion criteria: Personal, or first-degree relative with, diagnose of psychiatric conditions (schizophrenia, bipolar disorders). History of neurological disorders (including stroke, convulsion, epilepsy) as well as concussion with loss of consciousness. Used psychotropic drugs or medications over a period of 1 week prior to each test session. Currently using substances interacting with the metabolism of psilocybin or the serotonergic system (e.g. monoamine oxidase inhibitors, SSRIs). Contraindications for 7T MRI (e.g. claustrophobia, osteosynthetic material, pacemaker, artificial cardiac valves, pregnancy, tinnitus). Significant previous adverse response to a psychotropic substance. Significant previous adverse response to fMRI scanning. Participant does not speak English.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| * Relation of pRF parameter changes with psychophysical measures of low-and high level visual and somatosensory perception. * Relation of pRF parameter changes with questionnaire on subjective experience. * Relation of pRF parameter changes with 5-HT receptor maps. * Changes in location, extent and connectivity profile of category-specific regions in higher-level visual cortex * Changes in somatotopic maps: location, extent and overlap between cortical activations relating to stimulation of individual digits | — |
Primary
| Measure | Time frame |
|---|---|
| * Changes in population receptive field parameters exerted by psilocybin administration. * Relation with computational aspects of Divisive Normalization pRF model. | — |
Countries
Netherlands
Outcome results
None listed