lung inflammation pneumonia
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Healthy individual between 18 and 60 years of age - Non-smoker or ex-smoker (>2 years) - BMI 17-30 kg.m2
Exclusion criteria
Exclusion criteria: - History of respiratory diseases - History of bleeding disorder - Using anti-inflammatory and/or anticoagulant medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of immunometabolic pathways in alveolar macrophages of healthy volunteers using an integrative approach (in vitro analysis of the inflammatory and metabolic response to various stimuli and modulators). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Composition and diversity of the lung microbiome from BAL-fluid. 2. In vivo visualization of the healthy alveolar compartment and airway wall layers using biopsies, Optical Cohorence Tomography (OCT) and Confocal Laser Endomicroscopy (CLE). | — |
Countries
Netherlands
Outcome results
None listed