chronic obstructive pulmonary disease emphysema and chronic bronchitis.
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - COPD patient admitted to the hospital for an acute exacerbation - A physician diagnosed COPD according to the GOLD 2017 guidelines - Age >40 years - Smoker or ex-smoker, >10 pack years of smoking
Exclusion criteria
Exclusion criteria: - Current asthma or prior physician diagnosis of asthma without a symptom-free interval of at least 10 years before the age of 40 - Use of systemic corticosteroids >-4 days prior to hospital admission - Necessity (upon hospitalization) for non-invasive ventilation or ICU admission - Pneumonia at hospital admission, defined by the clincal presentation and the presence of a lobar consolidation on radiographical imaging - Any other clinically relevant lung disease deemed to interfere with the concept of the study design - Pregnancy and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression differences in sputum and nasal epithelium between eosinophilic COPD exacerbations and other subtypes. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Microbiome composition and immunophenotyping profiles of the different subtypes, i) eosinophilic, ii) viral, iii) bacterial, iv) pauci-inflammatory. 2. Course and duration of symptoms, measured by changes in peak flow and CAT scores. 3. RNA sequencing in nasal epithelium and sputum, and immunophenotyping in blood. 4. Differences in the sputum and nasal epithelial microbiome between COPD exacerbation subtypes, both during stable state and exacerbations. 5. Per subtype: course and duration of symptoms (CAT questionnaire), and lung function recovery after exacerbation, duration of hospital admission, risk of 2nd exacerbation during the follow-up. | — |
Countries
Netherlands
Outcome results
None listed