Single-dose preoperative partial breast irradiation in low-risk breast cancer patients

Single-dose preoperative partial breast irradiation in low-risk breast cancer patients - ABLATIVE-2

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON54083

Enrollment

Registered

2021-07-30

Start date

2022-08-24

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer breast carcinoma breast cancer

Interventions

MR-guided single dose preoperative radiotherapy 20 Gy to the tumor.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Female, 40 years or older, breast cancer, ER positive tumor, HER2-negative  tumor, maximal tumorsize 2 cm, Bloom Richardson grade 1 or 2, no (lympho)vascular invasion

Exclusion criteria

Exclusion criteria: Indication for chemotherapy, lobular carcinoma, previous breast cancer, lymph node or distant metastasis, breast cancer gene mutation, previous irradiation of chest wall, breast implant.

Design outcomes

Primary

Measure	Time frame
Rate of patients with pathologic complete response (pCR) following the single-dose preoperative radiotherapy treatment.	—

Secondary

Measure	Time frame
Radiologic response, pathologic response in irradiated tumor tissue and excision specimen, immune response, circulating tumor DNA, toxicity, cosmetic result, quality of life, anxiety and depression, local and regional recurrence, disease free survival, overall survival.	—

Countries

Australia, Netherlands

Contacts

Public ContactH.J.G.D. Bongard

Amsterdam UMC

h.j.vandenbongard@amsterdamumc.nl020-4441571

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Mar 20, 2026