hyperactive nodule thyroid lump
Conditions
Interventions
Patients agreeing to participate in randomization will be randomized to receive
treatment with either RAI (group 1), or RFA (group
2). Patients declining randomization but agreeing to follow-up will
Sponsors
Rijnstate Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age > 18 years - Hyperthyroidism or subclinical hyperthyroidims caused by a solitary hyperactive thyroid nodule (HTN), either located in an otherwise normal thyroid gland, or in a multinodular goitre (MNG) - Treatment with RAI indicated and eligible for RFA - Signed informed consent
Exclusion criteria
Exclusion criteria: - Multifocal HTN - HTN > 50 mm - Presence of a medical device susceptible to disturbances caused by RFA generated currents - Patients with physical or behavioural disorders that preclude safe isolation in radiation protection rooms, or safe RFA procedure under local anesthesia - Uncorrectable hemorrhagic diathesis - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of irreversible hypothyroidism | — |
Secondary
| Measure | Time frame |
|---|---|
| - one year cure rate - course of thyroid function - nodule volume - treatment related thyroiditis - adverse effects - standardized iodine versus local iodine - cost effectiveness - (thyroid related) quality of life - factors for implemantation | — |
Countries
Netherlands
Outcome results
None listed