Electrophysiological markers of cortical excitability to predict response to treatment with anti-seizure medication

Electrophysiological markers of cortical excitability to predict response to treatment with anti-seizure medication - The eCORTA Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54069

Enrollment

Registered

2022-01-26

Start date

2022-03-12

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy seizures

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In agreement with their own neurologist to initiate adjuvant treatment with cenobamate, diagnosed with focal epilepsy, age of 18 years or older, having kept a seizure diary for the past 12 weeks, at least one seizure in the past 12 weeks.

Exclusion criteria

Exclusion criteria: Photosensitive epilepsy, Cochlear implants, implanted neurostimulator or metal in the brain or skull, persistent skull opening following trauma or surgery, cardiac pacemaker, intracardiac lines, evidence (clinical or radiological) of major structural abnormality of the motor cortex or pyramidal tracts, any major psychiatric or neurological (other than epilepsy) condition, pregnancy, learning disabilities.

Design outcomes

Primary

Measure	Time frame
Change in cortical excitability parameters using TMS-EEG/EMG concerning treatment response.	—

Secondary

Measure	Time frame
- Change in cortical excitability parameters using VEP-EEG, task and resting state EEG in relation to treatment response - Utility of excitability parameters at T1 and optional T2 to predict treatment response on the long term by comparing measures between T0, T1 and optional T2 to seizure reduction after 12 months - Change in rMT between T0 and T1 correlated to change in seizure frequency in percentage - Change in scores calculated from the used questionnaires to determine anxiety, seizure severity and QOL	—

Measure

Time frame

- Change in cortical excitability parameters using VEP-EEG, task and resting state EEG in relation to treatment response - Utility of excitability parameters at T1 and optional T2 to predict treatment response on the long term by comparing measures between T0, T1 and optional T2 to seizure reduction after 12 months - Change in rMT between T0 and T1 correlated to change in seizure frequency in percentage - Change in scores calculated from the used questionnaires to determine anxiety, seizure severity and QOL

—

Countries

Netherlands

Outcome results