cerebrovascular accident, Ischemic stroke
Conditions
Interventions
 
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients with a first-ever transient ischemic attack (TIA) or acute ischemic stroke aged between 18 and 50 years old will be included. For this study, acute stroke is defined as "occurence of acute neurological deficit lasting more than 24 hours, with confirmation on imaging (CT(-a) or MR(-a))".TIA is defined as "occurence of acute neurological deficit lasting less than 24 hours with confirmation of ischemia on MRI). Patients are able to provide informed consent and a kidney function eGFR>30ml/min.
Exclusion criteria
Exclusion criteria: Main exclusion criteria are: history of clinical TIA, ischemic stroke or intracerebral hemorrhage. A intracerebral hemorrhage resulting from trauma, known aneurysm or underlying intracerebral malignancy. A venous infarction, retinal infarction and amourosis fugax. Inadequate control of the Dutch language to reliably sign an informed consent from and/or participate in the follow-up. Patients are excluded if they have a contra indication for 3T MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| What is the role of the immune system in the cause of a first-ever ischemic stroke or TIA before their 50th year? | — |
Secondary
| Measure | Time frame |
|---|---|
| • What is the role of triggerfactors on the immune system in patients with a first-ever ischemic stroke or TIA before their 50th year? • What is the role of the immune system on the vascular wall function in patients with a first-ever ischemic stroke or TIA before their 50th year? • What is the risk of long term complications in patients who suffer from an ischemic stroke or TIA between their 18th and 50th year? • What is the impact of a first-ever ischemic stroke or TIA before their 50th year on the functional prognosis? • What is the effect of coping strategies on cognitive and functional prognosis in patients with a first-ever ischemic stroke or TIA before their 50th year? | — |
Countries
Netherlands
Contacts
Public ContactJ.P. Spiegelenberg
Radboud Universitair Medisch Centrum
Outcome results
None listed