Primary Cerebral Lymphoma at UMCU and St Antonius

Primary Cerebral Lymphoma at UMCU and St Antonius - PRICELUS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54051

Enrollment

150

Registered

2021-01-27

Start date

2021-02-10

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain lymphoma Primary Central Nervous System Lymphoma (PCNSL)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Suspected or confirmed primary central nervous system lymphoma 2. Age > 18 years 3. Patients who have a clinical indication for a diagnostic lumbar puncture

Exclusion criteria

Exclusion criteria: 1) If contra-indications for lumbar puncture are present: - skin infection - coagulopathy - signs or symptoms of increased intracranial pressure - midline shift or obliteration of basal cisterns on neuro-imaging 2) If a patient is unwilling to give written consent.

Design outcomes

Primary

Measure	Time frame
Detect specific biomarkers in CSF and/or blood from patients clinically suspected of primary central nervous system lymphoma. Thereby improving the diagnosis of CNS lymphoma in a majority of patients and reducing the need for tissue confirmation through stereotactic biopsy.	—

Secondary

Measure	Time frame
Possible secondary objectives: - determine the relationship between the prognosis of CNS lymphoma and specific biomarkers, - determine the relationship between specific biomarkers and therapy response.	—

Countries

Netherlands

Outcome results