chronic kidney failure high blood pressure
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy individuals: 18-80 years; eGFR above 60 ml/min/1.73m2 without albuminuria. CKD patients: 18-80 years; eGFR 15-60 and/or albuminuria (albumine >30 mg/24h or albumine-creatinine ratio >3 mg/mmol).
Exclusion criteria
Exclusion criteria: Healthy individuals: albuminuria; BMI > 30 kg/m2; office blood pressure > 140/90 mmHg; history of diabetes mellitus, hypertension, kidney disease, cardiovascular disease, restrictive dietary habits, eating disorders and/or food allergies; use of systemic glucocorticoids, antihypertensive and/or antidiabetic medication. CKD patients: office blood pressure > 180/100 mmHg; suffering of acute kidney injury; changes in antihypertensive medication in the last 2 months; use of systemic glucocorticoids; dialysis treatment or expected initiation of dialysis within 3 months of screening; a history of restrictive dietary habits, an eating disorder or food allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome of this study is the difference between measured dietary Na+ and K+ intake and estimated Na+ and K+ intake, using multiple estimation methods. We will compare the abovementioned outcomes in healthy individuals and individuals with chronic kidney disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will compare methods for dietary Na+/K+ ratio estimation: single or repeated 24-hour measurement and single or repeated spot urine measurement. We will investigate the potential value of the urine Na+/K+ ratio as compared to separate urine Na+ and K+ measurements. We will investigate the effects of correcting 24-hour Na+ and K+ excretion for 24-hour aldosterone and cortisol excretion. We will compare the abovementioned outcomes in healthy individuals and individuals with chronic kidney disease. | — |
Countries
Netherlands
Outcome results
None listed