The HCBx permanent AF substudy: The contribution of AF related hemodynamics to structural brain abnormalities and cognitive function decline

The HCBx permanent AF substudy: The contribution of AF related hemodynamics to structural brain abnormalities and cognitive function decline - The HBCx Permanent AF substudy - MIND AF

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54040

Enrollment

103

Registered

2021-12-22

Start date

2022-02-16

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

a-fib atrial fibrillation cognitive impairment memory disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age 60-80 years (stratified in 60-65, 66-70, 71-75, 76-80 years, minimal 20 patients per group) Knowledge of Dutch language Permanent AF Able to undergo MRI Able to undergo cognitive testing Mandatory use of coagulation Gender stratification 50/50 (bandwidth 40%-60%)

Exclusion criteria

Exclusion criteria: A clinical diagnosis of dementia is a contra-indication for participation in this study Other neurological or psychiatric diagnosis that affects cognitive performance or testing, such as severe traumatic brain injury or substance abuse A history of stroke A pacemaker/ICD in situ >5% ventricular pacing Severly impaired LVEF PVI or CABG in the past three months

Design outcomes

Primary

Measure	Time frame
Cognitive functioning at baseline and cognitive decline at two year follow up measured with neuropsychological assessment.	—

Secondary

Measure	Time frame
Heart rate variability and irregularity Peripheral blood pressure variation Structural brain abnormalities Risk factors	—

Countries

Netherlands

Outcome results