Lung cancer tumour material
Conditions
Interventions
There is no intervention or research product. An extra tube of blood will be withdrawn from an existing line during a regular diagnostic procedure.
Sponsors
Maastro
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • All patients selected to undergo primary surgical resection of a primary lung cancer. All types of resection are eligible, e.g. wedge resection, segmental resection, lobectomy, pneumonectomy. • All patients with (suspected) lung cancer that will undergo a bronchoscopy or endobronchial ultrasound guided transbronchial needle aspiration (EBUS/EUS-TBNA) bronchoscopy.
Exclusion criteria
Exclusion criteria: - Incompetent -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To establish matched normal and primary human lung cancer tumoroids from patient-derived (tumor) tissue material | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To define oncogenic drivers in lung cancer tumoroids 2. To investigate the stability of (epi-) genetic and phenotypic tumor heterogeneity of cultured tumoroids compared to a primary/secondary biopsy. 3. To predict sensitivity and to get insight in the molecular biology of the response to immunotherapy, radiotherapy, cytotoxic and targeted agents. 4. To compare treatment response in normal lung organoids and lung cancer tumoroids 5. To develop biomarker(s) of tumor response to be able to select patients who will benefit from novel treatment strategies. 6. To analyze (ct)DNA, RNA, proteins, metabolites, and microvesicles secreted by lung cancer cells in tumoroids-derived culture supernatants and corresponding patient-derived blood samples. | — |
Countries
Netherlands
Contacts
Public ContactC. Overhof-Wedick
Maastro
Outcome results
None listed