Diagnostic accuracy of MRI for neurodegenerative parkinsonism

Diagnostic accuracy of MRI for neurodegenerative parkinsonism - MRPARK

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54005

Enrollment

180

Registered

2022-01-21

Start date

2022-05-23

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

idiopathic parkinson's disease neurodegenerative parkinsonism Parkinsons disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age above 18 - DAT-SPECT scan between January 2019 and December 2021 for clinical uncertain parkisonian syndrom

Exclusion criteria

Exclusion criteria: - Indication for the DAT-SPECT other than CUPS - Inability to provide informed consent - Aboslute contra indication for MRI

Design outcomes

Primary

Measure	Time frame
The diagnostic accuracy of the automated diagnostic software (mPDia, Heuron) using SMWI, compared with the final diagnosis of the neurologist.	—

Secondary

Measure	Time frame
- Contrast ratio and size of the SN and LC on nmMRI - Iron content of SN and basal ganglia on SWI using QSM - T1 and T2 relaxation in different brain regions using MR STAT - Free-water present in the SN on DTI - Architecture of white matter tracts on DTI - Contrast ratio and size of the SN on nmSMWI - Hoehn & Yahr stage - MDS UPDRS that consists of the following four parts will be filmed: I. Non-motor experiences of daily living (6 items) II. Motor experiences of daily living (20 items) III. Motor examination (33 items) IV. Motor complications (6 items) - Red flags on the MDS criteria for the diagnosis of PD3 - Montreal cognitive assessment (MoCA) - REM sleeping behavior disorder screening - Non-motor symptom assessment scale - Beck Depression inventory (BDI) - Environmental factors - Sebum swap	—

Measure

Time frame

- Contrast ratio and size of the SN and LC on nmMRI - Iron content of SN and basal ganglia on SWI using QSM - T1 and T2 relaxation in different brain regions using MR STAT - Free-water present in the SN on DTI - Architecture of white matter tracts on DTI - Contrast ratio and size of the SN on nmSMWI - Hoehn & Yahr stage - MDS UPDRS that consists of the following four parts will be filmed: I. Non-motor experiences of daily living (6 items) II. Motor experiences of daily living (20 items) III. Motor examination (33 items) IV. Motor complications (6 items) - Red flags on the MDS criteria for the diagnosis of PD3 - Montreal cognitive assessment (MoCA) - REM sleeping behavior disorder screening - Non-motor symptom assessment scale - Beck Depression inventory (BDI) - Environmental factors - Sebum swap

—

Countries

Netherlands

Outcome results