Identifying neural mechanisms associated with cancer-related fatigue: a cross-sectional study in testicular cancer survivors

Identifying neural mechanisms associated with cancer-related fatigue: a cross-sectional study in testicular cancer survivors - Neural mechanisms of cancer-related fatigue

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53997

Enrollment

Registered

2021-08-30

Start date

2022-05-04

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kanker-gerelateerde vermoeidheid cancer-related fatigue

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: For all participants: • Written informed consent • Male • Age between 18 and 50 yrs • Sufficient command of the Dutch language (to answer questionnaires) For patients: • Unilateral orchiectomy • 3 or 4 cycles of BEP or EP treatment regimen

Exclusion criteria

Exclusion criteria: For all participants: • Presence of acute infection or inflammation on day of testing (body temperature >38) • Current use of prescribed psychotropic, pain or anti-inflammatory drugs • (history of) long-term (> 6 months) daily use of over-the-counter NSAIDs (ibuproven, diclofenac, naproxen) (for patients: besides those used during cancer-treatment) • Current use of over-the-counter corticosteroids, anti-histamic or anti-inflammatory drugs (participants that use corticosteroid moistures or hay-fever drugs are asked to not use it on the testing day) • Obesity (BMI>30) • (history of) metabolic disease (e.g. diabetes) • (history of) cardiovascular events • (history of) neurological or psychiatric symptoms/disease • (history of) chronic inflammatory disease (e.g. rheumatoid arthritis, Crohns disease) • (history of) hypo/hyperthyroide • (history of) chronic pain (>6 months) (for patients before diagnosis) • (history of) chronic fatigue syndrome or fibromyalgia (for patients before diagnosis) • (history of) hypogonadism/ hormonal disturbance or supletion (for patients before diagnosis) • Metal objects in or around the body • Claustrophobia • Glaucoma or increased risk for glaucoma • No presence of metastatic disease or relapse • No patients who received radiotherapy because other treatment with different side effects

Design outcomes

Primary

Measure	Time frame
- Task-related activity during effort-based decision making - Self-reported fatigue	—

Secondary

Measure	Time frame
- Individual levels of high-sensitive C-reactive protein (CRP) on testing day - Resting-state functional connectivity patterns	—

Countries

Netherlands

Outcome results