pulmonary embolisms
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Adult >=18 years and declared competent - Provided written informed consent - Referred to the Nuclear Medicine Department for a conventional V/Q-SPECT/CT - Indication for conventional V/Q-SPECT/CT includes known or suspected pulmonary embolism
Exclusion criteria
Exclusion criteria: - Pregnancy - Children or adolescents (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigate and define optimal image acquisition parameters for V/Q PET/CT. Within the two patient groups, different technical parameters will be applied during image acquisition and post-processing. After enrolment of the final participant (#20) and image acquisition, all imaging studies will be presented to two independent nuclear medicine physicians, for a blinded assessment, presented in a random order. During the first assessment round; Independent physicians should grade subjective image quality according to a five-point Likert scale (ranging from very poor to very good). During a second assessment round; Independent physicians should grade image quality, compared to the current clinical standard (V/Q-SPECT). Finally, in the same round as the second assessment, physicians should report whether or not additional perfusion and/or ventilation defects could be acknowledged. Besides subjective image quality assessment, (semi-)quantitative measurement will be performed by a medical physicist (e.g. signal-to-noise ratio, etc.) | — |
Secondary
| Measure | Time frame |
|---|---|
| Confirm feasibility of 68Ga-MAA and Galligas (preparation for administration and administration at the aimed time points). This will be derived from the radionuclide pharmacy (RNA) log and weekly radiopharmaceutical meetings within the department. Confirm logistical advantages of 68Ga-V/Q-PET/CT over 99mTc-V/Q-SPECT/CT. Differences in total acquisition times will be gathered and compared by a simple two-sided t-test; total scanning time per separate procedure (99mTc-MAA/99mTechnegas/68Ga-MAA/68Galligas) and a combination of scans (V/Q-SPECT/CT vs V/Q-PET/CT). Additionally, total procedure time will be gathered and compared in a similar fashion. Registration of both acquisition times and procedure times are standard practice and can be directly derived from the imaging archive (Sectra PACS) or medical record files (HiX, Chipsoft). | — |
Countries
Netherlands
Outcome results
None listed