Measuring blood-brain barrier integrity non-invasively with MRI

Measuring blood-brain barrier integrity non-invasively with MRI - COGA BBB-MRI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53975

Enrollment

204

Registered

2023-03-03

Start date

2023-04-25

Completion date

Unknown

Last updated

2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dementia early cognitive decline

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria of the COGA study includes all patients who consent to their data being released for scientific research, by signing the informed consent for the general protocol (METC 2017.148)

Exclusion criteria

Exclusion criteria: Contraindications for MRI, such as claustrophobia or the presence of metal in the body.

Design outcomes

Primary

Measure	Time frame
The main study parameters are the exchange time maps, measured in ms (as a surrogate measure of permeability).	—

Secondary

Measure	Time frame
Quantified perfusion maps in the units mL/100gm/min, and arterial transit time maps, also measured in ms, reflecting the amount of time spins take to travel from the labeling plane to imaging plane.	—

Countries

Netherlands

Outcome results