Migraine
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Females aged between 18 and 40 years; • Non-smoking; • Body mass index 18-30 kg/m2; • All females should have a regular menstrual cycle and not using oral contraceptives. Measurements will be performed in the middle of their cycle; • Capable and willing to give written informed consent; • General good health (as specified in the exclusion criteria), based on their (self-reported) medical history.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • A history of migraine or current migraine (including aura without headache), as determined with the official International Criteria of Headache Disorders (version 3); • Medical history or self-reported symptoms of conditions related to (peripheral) vascular disease or any hormonal disorders, e.g. cardio- or cerebrovascular events, peripheral arterial disease, chronic kidney disease, (pre)diabetes mellitus, uncontrolled chronic hypertension, congestive heart failure, hyperlipidaemia, hypercholesterolemia, a history of ischemic stroke, preeclampsia or PCOS, adrenal insufficiency, hyperthyroidism, hypothyroidism, et cetera; • Use of any vasoactive drugs (including nonsteroidal anti-inflammatory drugs (NSAIDs)) for
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The maximal DBF value (Emax) in response to capsaicin and electrical stimulation will be calculated for every participant. | — |
Secondary
| Measure | Time frame |
|---|---|
| The association of hormone levels and oxytocin levels with DBF measurements, considering their possible interactions with the CGRP system. | — |
Countries
Netherlands
Outcome results
None listed