pollen-food-syndrome treepollen related food allergy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Adults (18 years or older) with allergic rhinitis for treepollen who will start with Itulazax (SLIT treepollen). - Pollen-food synrome for at least one of the cross-related allergens with birchpollen (bet v1) and sensibilisation in skinpricktesting or ImmunoCAP. - The abbility to sign informed consent.
Exclusion criteria
Exclusion criteria: - Patients with allergic rhinitis without treepollensensibilisation. - Patients with allergic rhinitis, but without food allergy. - Patients with a contraindication for Itulazax (due to the SMPC) - Patients younger 65 years - Patients with chronic spontaneous urticaria and/or chronic spontaneous angiooedema. - Patients who do not speak the Dutch language. - Patients who do not want or are able to sign the informed consent - Patient with previous treatment of subcutaneous immunotherapy birchpollen in the last 3 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Does the use of Itulazax 12 SQ-Bet lyophilisate (a sublingual tree pollen immunotherapy) in adults with allergic rhinitis and paraberk syndrome affect the pollen-food-syndrome? Primary outcome measure In patients treated for allergic rhinitis with Itulazax who also have pollen-food-syndrome, what is the effect on food allergy-related quality of life at 1 and 3 years relative to baseline as measured by the Food Allergy Quality of Life Questionnaire - Adult Form ( FAQLQ-AF). | — |
Secondary
| Measure | Time frame |
|---|---|
| o In patients treated with Itulazax for allergic rhinitis who also have pollen-food-syndrome, what is the effect on: - The threshold of food allergy - Severity of food allergy - Time that the complaints persist - Height of specific IgE - Size of skin reaction after skin test - Possibility of ingestion of fresh/raw products in the context of pollen-food-syndrome that previously gave complaints - The basophil activation test (BAT) in hazelnut-allergic patients o Which factors (including demographic factors, skin test, sIgE in blood, severity of food allergy, type of food) are related to a good effect of Itulazax on pollen-food-syndrome? o Does the patient's expectation of the effect of Itulazax on food allergy symptoms influence the primary and secondary outcome measures? | — |
Countries
Netherlands
Outcome results
None listed