GUS metabolisme in case of increased pectin intake
Conditions
Interventions
the eating of two apples a day during a period of 6 weeks
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age 50-64 Postmenopausal women Recent negative breast cancer screening (
Exclusion criteria
Exclusion criteria: Previous gastrointestinal surgery (excl. appendix surgery) any type of cancer in history, except for basal cell carcinoma (BCC) inflammatory bowel disease mammography older than 6 months antibiotic use within three months before fecal sampling physically or mentally incapable or incompetent to sign informed consent known apple allergy or complaints matching with apple allergy less good dental state the regularly consumption of 1 or more apples a day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints: - Significant decrease in the activity of the bacterial enzyme β-glucuronidase and the abundance of β-glucuronidase-producing bacteria - Assessment with WMGS of the gut microbiota composition, diversity, and functional capacity - The frequency of the eating of two apples a day | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: - Significant increase of SCFA - Significant change in dietary intake, medication, stool classification and frequency, blood pressure, weight and quality of life | — |
Countries
Netherlands
Outcome results
None listed