cognitief functioneren not applicable
Conditions
Interventions
50 will undergo a single session of inhibitory rTMS to the dorsolateral 
prefrontal cortex (DLPFC)
50 will be active controls (through use of a sham 
coil).
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Age between 20 and 65 years old * Native Dutch speaker * Able to provide written informed consent.
Exclusion criteria
Exclusion criteria: * Current diagnosis of neurological or psychiatric disease (including traumatic head injury) * Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including use of alcohol ~8 hours prior to an appointment * Presence of any contraindications for MRI, MEG, or TMS (including resting-motor threshold >75% of maximum stimulator output or no useful motor-evoked potential elicitable) * Previous rTMS treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary effect of rTMS will be assessed through the change in performance on a neuropsychological test measuring executive functioning in the domain of executive functioning pre- and post-intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondarily, changes in network organization will be characterised by (multimodal) neuroimaging pre- and post-treatment. Pre-treatment imaging will include magnetoencephalography (MEG), diffusion MRI (dMRI), task-based functional MRI (tbfMRI), and resting state fMRI (rsfMRI); post-treatment imaging will include only tbfMRI. | — |
Countries
Netherlands
Outcome results
None listed