Preventie cardiometabole aandoeningen age-related muscle loss Sarcopenia
Conditions
Interventions
Self-composed fully plant-based (vegan) diet with or without concurrent RE.
Sponsors
Wageningen Universiteit
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Aged >=65 years old; - Community-dwelling; - BMI 23-32 kg/m2; - Habitual diet contains animal-based food products (i.e. dairy, meat and/or fish) at least 5 days per week;
Exclusion criteria
Exclusion criteria: - Following a self-reported entirely vegetarian or vegan diet during the six months prior to the study; - Following a prescribed high (>=1.2 g/kg/d) or low protein diet (below 0.8 g/kg/d), and/or or taking protein supplements on medical advice, during the month prior to the study; - Participating in a structured progressive resistance exercise training program the during three months prior to the study; - >=4 kg of body weight loss during three months before the start of the study; - Being diagnosed with one of the following: diabetes mellitus; severe renal disease (glomerular filtration rate below 30 ml/min) ; neurological or neuromuscular disorders; serious cardiovascular diseases; cancer (with the exception of the following types of skin cancer: basal cell carcinoma, squamous cell carcinoma); (very) severe chronic obstructive lung disease (COPD; GOLD stage III or IV); bowel disease. - Chronic use of medication that affects muscle function as assessed by the research physician; - The use of anticoagulants incompatible for muscle biopsies as assessed by the research physician: acenocoumarol (sintrom); phenprocoumon (marcoumar); dabigatran (pradaxa); apixaban (eliquis); rivaroxaban (xarelto); clopidogrel (plavix); edoxaban (lixiana); combination of acetylsalicylic acid or carbasalate calcium (ascal) with dipyridamole; - Having a contra-indication to MRI scanning (including, but not limited to): o Pacemakers and defibrillators o Infraorbital or intraocular metallic fragments o Ferromagnetic implants o Claustrophobia - Not willing to stop nutritional supplements, with the exception of supplements on medical advice, and vitamin D; - Not willing or afraid to give blood, undergo a muscle biopsy or have an MRI scan during the study; - Unwilling to eat a self-composed vegan diet or an omnivorous diet with daily consumption of animal-based food sources for 3 months; - Unwilling to participate in RE twice a week for 3 months; - Currently a research participant in another trial or participated in a clinical trial during one month before the start of the measurement period; - Not being able to understand Dutch; - Not having a general physician; - Working, or having a direct family member that works at the Division of Human Nutrition at Wageningen University during the study. - Unwilling to be informed about incidental findings of pathology and approving of reporting this to their general physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in change in TMV. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Other body composition indices from MRI-scan: thigh muscle fat infiltration, liver proton-density fat fraction, visceral adipose tissue, Abdominal subcutaneous adipose tissue - Muscle strength - Muscle fractional synthesis rates - Bone mineral density - Bone turnover markers (C-terminal telopeptide of type I collagen [CTX] and procollagen type I N-terminal propeptide [PINP]) - Insulin-like growth factor 1 (IGF-1) and parathyroid hormone (PTH) levels - Insulin levels - Dietary intake - Metabolic profile - Blood pressure - Iron status - Vitamin B12 status - Vitamin D status - Gastrointestinal symptoms - Gut metabolomics and metagenomics - High sensitive CRP - DNA methylation | — |
Countries
Netherlands
Outcome results
None listed