Vector Flow Imaging in healthy vessels

Vector Flow Imaging in healthy vessels - VFI in healthy vessels

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53908

Enrollment

Registered

2022-03-31

Start date

2022-11-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carotid or superficial femoral artery stenosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Healthy male or female, without cardiovascular and pulmonary medical history and without the use of medication for cardiovascular risk factors. - Age between 20-30 year or 65-75 years old - Willingness to undergo a 4D flow MRI scan and US examinations - Informed consent form understood and signed, and agrees to the hospital visit.

Exclusion criteria

Exclusion criteria: - Hypersensitivity to the active substance(s) of any of the excipients in Sonovue. - Pregnancy - MRI exclusion criteria (such as presence of pacemaker, cerebral vascular clips, claustrophobia).

Design outcomes

Primary

Measure	Time frame
Velocity vector data derived from bST, echoPIV and 4D flow MRI examinations at the CA and SFA will be used to calculate and visualize the spatiotemporal blood flow velocity profiles to assess the performance of the two VFI techniques compared to 4D flow MRI.	—

Secondary

Measure	Time frame
- Velocity vector data derived from bST and echoPIV at the CA and SFA will be used to calculate and visualize the spatiotemporal blood flow velocity profiles to assess the correlation between both VFI techniques. - Velocity vector data obtained with the bST, echoPIV and 4D flow MRI measurements at the CA and SFA will be used to calculate blood flow derived parameters, such as vector complexity, vorticity and WSS. These parameters will be compared between the different techniques and 4D flow MRI. - Spatiotemporal blood flow velocity profiles and blood flow derived parameters obtained at the CA and SFA using bST, echoPIV and 4D flow MRI will be compared between young and older healthy volunteers (group 1 and group 2). - Spatiotemporal blood flow velocity profiles derived from the bST data obtained at the CA by observer 1 and observer 2 will be used to assess the inter-observer variation. - Spatiotemporal blood flow velocity profiles derived from the bST data obtained two times at the CA by observer 1 will be used to assess the intra-observer variation.	—

Measure

Time frame

- Velocity vector data derived from bST and echoPIV at the CA and SFA will be used to calculate and visualize the spatiotemporal blood flow velocity profiles to assess the correlation between both VFI techniques. - Velocity vector data obtained with the bST, echoPIV and 4D flow MRI measurements at the CA and SFA will be used to calculate blood flow derived parameters, such as vector complexity, vorticity and WSS. These parameters will be compared between the different techniques and 4D flow MRI. - Spatiotemporal blood flow velocity profiles and blood flow derived parameters obtained at the CA and SFA using bST, echoPIV and 4D flow MRI will be compared between young and older healthy volunteers (group 1 and group 2). - Spatiotemporal blood flow velocity profiles derived from the bST data obtained at the CA by observer 1 and observer 2 will be used to assess the inter-observer variation. - Spatiotemporal blood flow velocity profiles derived from the bST data obtained two times at the CA by observer 1 will be used to assess the intra-observer variation.

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Countries

Netherlands

Outcome results