Internalising problems psychological distress
Conditions
Interventions
We will offer a mindfulness training program designed specifically for youth 
with internalizing problems. The Learning to Offset Stress (LOS) (in Dutch: 
Leren Omgaan met Stress) training program consists of a standard protocol based 
on mindfulness based cognitive therapy (MBCT) combined with mindful physical 
activity and yoga exercises. The 8-week training consists of weekly 2-hour 
sessions and daily home practice. The 8th session will signify the end of the 
training. After this last session participants are encouraged to continue home 
self-practice. After 8 weeks a 2 hour booster session is provided to reinforce 
mindfulness skills and to trouble-shoot with participants who experience 
problems with their practice. The control group will receive treatment as 
usual, mostly consisting of supportive counseling. When the study ends they 
will be offered to participate in the mindfulness training.The healthy control group will not receive an intervention
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: RCT participants (help-seeking youth) 1. Help-seeking youth between 16 and 25 years of age 2. Provide written informed consent 3. Adequate mastery of Dutch language Healthy control group participants: 1. Youth between 16 and 25 years of age 2. Provide written informed consent 3. Adequate mastery of Dutch language
Exclusion criteria
Exclusion criteria: RTC participants (help-seeking youth) 1. Lifetime diagnosis of severe major depression, bipolar disorder, schizophrenia spectrum disorder, personality disorder, and post-traumatic stress disorder 2. History of major medical illness or neurological illness 3. Participation in a mindfulness programme in the past year 4. Current participation in another intervention study 5. Moderate to severe substance use disorders (i.e., we will allow for mild substance use) 6. Current active suicidality, current psychotic symptoms above clinical cut-off for psychosis, or current trauma-related complaints above clinical cut-off for PTSD. 7. Diagnosed or suspected (mild) intellectual disability (estimated IQ < 75) Healthy control group participants: 1. Any lifetime mental illness 2. Having a first-degree family member with serious mental illness (i.e., major affective, psychotic or personality disorder) 3. Current clinical symptoms that fulfill any DSM-5 mental disorder criteria, as determined using the MINI-S-DSM-5 administered by a psychiatrist or resident in psychiatry 4. History of major medical illness or neurological illness 5. Participation in a mindfulness program in the past year 6. Diagnosed or suspected (mild) intellectual disability (estimated IQ<75) 7. Contraindications for MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total internalizing problems as measured using the Adult Self Report (ASR) is the primary outcome variable. | — |
Secondary
| Measure | Time frame |
|---|---|
| In a clinical interview, participants will be screened for DSM-5 diagnoses using the Mini International Neuropsychiatric Interview - Screen for DSM-5 (MINI-S-DSM-5). Mindfulness skills will be measured using The Five Facets of Mindfulness Questionnaire - short form (FFMQ - SF) and self-compassion will be measured using the Self-Compassion Scale (SCS). Overall mental well-being will be measured using the Mental Health Continuum - short form (MHC-SF). Rumination will be measured using the Rumination-Reflection Questionnaire (RRQ) - Brooding subscale. Stress levels will be measured using the Perceived Stress Scale - 10 item (PSS-10). Resilience will be measured using the Connors-Davidson Resilience Scale (CD-RISC). Self-esteem will be measured using the Rosenberg Self Esteem Scale (RSES). Adaptive self-concepts will be measured using the Adaptive Self-Concepts Questionnaire (ASCQ). Experiential avoidance will be measured using the Acceptance and Action Questionnaire (AAQ-II). Demographic data will be collected and the degree to which people adhere to the training curriculum (and continue mindfulness practice after completing the training) will be recorded using the Mindfulness Adherence Questionnaire (MAQ). In addition, a number of experimental tasks will be administered inside and outside of the MRI scanner. The Self-Referent Encoding Task (SRET), which measures biases in positive and negative self-related information processing, will be performed in the scanner. An escape and avoidance task designed to measure automatic avoidance behaviours will be performed outside the scanner. In addition, participants have the option to perform an online Pavlovian to Instrumental Transfer (PIT) task and controllability task (CBU).Finally, the main objectives of adding the HC group are to 1) recruit a sample of healthy youth (16-25 yo) to assess neurocognitive mechanisms associated with mental illness development in a normative sample, 2) determine how these mechanisms differ bet | — |
Countries
Netherlands
Contacts
Public ContactG. Collin
Radboud Universitair Medisch Centrum
Outcome results
None listed