breast cancer Mamma carcinoma breast cancer
Conditions
Interventions
4D dynamic contrast enhanced Breast CT
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Women >18 years old - Diagnosis of breast cancer - Treatment not yet initiated
Exclusion criteria
Exclusion criteria: - Suspected or confirmed pregnancy - Women who are breastfeeding - Women who have had bilateral mastectomy - Women who cannot give informed consent - Contra-indication for iodine contrast (i.e., contrast allergy, renal function impairment (GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part A: Detection of additional tumor foci and tumor centers in either breast. Part B: The prediction of final outcome at each imaging time point, and identification of the markers that allow for prediction of final outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Part A: o The frequency and appropriateness of change in surgical planning. o The identification of imaging biomarkers that characterize tumor molecular profiles at the sub-tumor level. o Determination of local cell density and vascular access to the different tumor regions. o Comparison of the results obtained from the 4D DCE-BCT and DCE-MRI. Part B: Direct comparison of the predictive and classification ability of 4D DCE-BCT and DCE-MRI for therapeutic response to NAT. | — |
Countries
Netherlands
Contacts
Public ContactL.D. Dolman-Mauritz
Radboud Universitair Medisch Centrum
Outcome results
None listed