Decreased immune response
Conditions
Interventions
The intervention groups will receive soft chews containing 0.5 gr plant stanols
per chew (present as plant stanol esters esterified to rapeseed oil fatty
acids) and are required to take 4, 6 or 8 ch
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 60 years or older in influenza season (2022/2023), BMI 20-35 kg/m2, not using products with added plant sterols or plant stanols, willing to abstain from products with added plant sterols or plant stanols during study, willing to keep intake of fish oil and vitamin supplements constant during study
Exclusion criteria
Exclusion criteria: Already received influenza vaccination, already had influenza in 2022, allergy to an ingredient of the soft chews, excessive alcohol use (>20 consumptions per week), regular use of drugs, blood donors that want to donate one month prior to or during the study, Known allergic reaction to an active component or other components of the vaccine (e.g. chicken eggs)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study outcome is the vaccination response to the influenza vaccine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include amongst others, hematological, inflammatory and immunological parameters (e.g. hs-CRP, leukocyte differential count, cytokines) and metabolic markers (e.g. blood lipid profiles, plasma glucose). | — |
Countries
Netherlands
Outcome results
None listed