Retro-PROFIT; PReservation Of female Fertility In oncologic Treatment Fertility, pregnancy and quality of life after fertility-sparing treatment for gynaecological cancer.

Retro-PROFIT; PReservation Of female Fertility In oncologic Treatment Fertility, pregnancy and quality of life after fertility-sparing treatment for gynaecological cancer. - Retro-PROFIT; PReservation Of female Fertility In oncologic Treatment

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53845

Enrollment

1030

Registered

2022-10-19

Start date

2022-11-22

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical cancer endometrial cancer gynaecological cancer ovarian cancer

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Women with cervical, ovarian or endometrial cancer - Age between 18-39 at time of diagnosis - Fertility-sparing treatment between 2000 and 2020

Exclusion criteria

Exclusion criteria: For the questionnaire and interviewstudy: - Living abroad and untraceable at time of data collection - Deceased at time of data collection - Insufficient understanding of the Dutch language

Design outcomes

Primary

Measure	Time frame
Q1: 2-year and 5-year recurrence free survival Q2:Percentage of women trying to conceive, within this group: pregnancy rate (number of first pregnancies after treatment divided by the number of women who tried to conceive) and number of pregnant women divided by the number of women who tried to conceive after treatment. Live birth rate Q3:Initiation of pursuing pregnancy Psychological outcome: reproductive concerns, anxiety and depression, cancer worries and decisional regret.	—

Measure

Time frame

Q1: 2-year and 5-year recurrence free survival Q2:Percentage of women trying to conceive, within this group: pregnancy rate (number of first pregnancies after treatment divided by the number of women who tried to conceive) and number of pregnant women divided by the number of women who tried to conceive after treatment. Live birth rate Q3:Initiation of pursuing pregnancy Psychological outcome: reproductive concerns, anxiety and depression, cancer worries and decisional regret.

—

Secondary

Measure	Time frame
Q1: 2- and 5-year survival and overall survival Q2:Type of conception (artificial or spontaneous) Miscarriages, gestational age at delivery (preterm	—

Countries

Netherlands

Outcome results