muscle anabolism Muscle growth
Conditions
Interventions
All subjects will consume a standardized low-protein diet (
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Male • Age between 18 and 35 y inclusive • BMI between 22 and 30 kg/m2 • Non-smoker • Having given informed consent
Exclusion criteria
Exclusion criteria: • Participating in a structured (progressive) exercise program • Smoker • Diagnosed GI tract disorders or diseases • Diagnosed musculoskeletal disorders • Diagnosed metabolic disorders (e.g. diabetes) • Cardiovascular disease • Hypertension (blood pressure above 140/90 mmHg) • Donated blood 3 months prior to test day • Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories). • Chronic use of gastric acid suppressing medication • Chronic use of anti-coagulants • Any intolerance to foods included in the standardized diet intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skeletal muscle protein synthesis rates | — |
Secondary
| Measure | Time frame |
|---|---|
| - Skin protein synthesis rates - Muscle mass - Resting energy expenditure - Blood pressure and heart rate - Plasma profiles (lipids, insulin, amino acids, inflammatory markers) - Urine markers of protein breakdown - Skeletal muscle mitochondrial respiration - Organ volumes - Biochemical signaling pathways in skeletal muscle | — |
Countries
Netherlands
Outcome results
None listed